Endocrine Abstracts

Vandetenib has been used as novel treatment of locally invasive medullary carcinoma of thyroid. We report the use of Vandetenib in a paediatric patient with inoperable medullary carcinoma of thyroid gland. Our patient presented to the dental surgeons at age 12 years with tongue and lip swellings. Biopsy demonstrated mucosal neuromas suggestive of MEN2B. He was clinically euthyroid but had a firm goitre. Ultrasound showed a large heterogenous thyroid mass encasing the common ca...

Background: All children with Growth Hormone Deficiency (GHD) should have a Magnetic Resonance Imaging (MRI) scan performed as standard (GH Research Society, 2000).Aims: To determine whether all patients diagnosed with GHD as determined by stimulation testing had an MRI scan performed; and to examine the relationship between the results of endocrine investigations and MRI scans.Methods: Retrospective review of all children who had ...

Background: Calculation of a urinary steroid metabolite ratio (uSMR) may be a useful method of improving diagnostic yield when investigating disorders of steroid hormone synthesis.Objective & HypothesisTo investigate the range of uSMR in children with suspected disorders of steroid hormone synthesis.Population / MethodsTen ratios were calculated on steroid metabolite data analysed b...